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Review copy

30,80 €
ISBN 978-3-8440-0779-4
Softcover
150 pages
48 figures
221 g
21 x 14,8 cm
English
Thesis

February 2012

Solvey Maldonado Torres

Force-induced Bone Adaptation:
A Systems Biology Perspective Towards Therapy Design

In this work, the author employs a systems biology approach to get a system-level understanding of the biological mechanisms driving the adaptive response of bone to increased/decreased mechanical loads. To this end, a mathematical model describing the adaptation of bone due to mechanical and chemical stimuli is developed and qualitatively validated. Novel set-based methods are employed to analyze the steady state effects of parameter uncertainty and robustness of the model. Furthermore, these set-based methods are used to explore the design of new treatments combining the beneficial effects of mechanical and non-mechanical agents for specific bone disorder conditions.

Keywords: bone remodeling; bone adaptation; mechanical loading; sensitivity analysis; rational/polynomial systems; semidefinite programming; convex relaxations; set-based methods

Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg

Edited by Otto-von-Guericke Universität Magdeburg and Institut für Automatisierungstechnik, Magdeburg

Volume 2

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Solvey Maldonado Torres

Force-induced Bone Adaptation: A Systems Biology Perspective Towards Therapy Design

Force-induced Bone Adaptation:
A Systems Biology Perspective Towards Therapy Design