Matthias J. Eicke

Process Strategies for Batch Preferential Crystallization

ISBN:

978-3-8440-4896-4

Series:

Forschungsberichte aus dem Max-Planck-Institut für Dynamik komplexer technischer Systeme
Herausgeber: Prof. Dr. Peter Benner, Prof. Dr.-Ing. Udo Reichl, Prof. Dr.-Ing. Andreas Seidel-Morgenstern and Prof. Dr.-Ing. Kai Sundmacher
Magdeburg

Volume:

Keywords:

Enantiomers; Preferential Crystallization; Modeling and Simulation; Chemical Engineering

Type of publication:

Thesis

Language:

English

Pages:

170 pages

Figures:

77 figures

Weight:

253 g

Format:

21 x 14,8 cm

Bindung:

Paperback

Price:

48,80 € / 61,10 SFr

Published:

December 2016

Buy:

DOI:

10.2370/9783844048964 (Online document)

Download:

Available PDF-Files for this title:

You need the Adobe Reader, to open the files. Here you get help and information, for the download.

These files are not printable.


	Document		Document
	Type		PDF
	Costs		36,60 EUR
	Action		Purchase in obligation and display of file - 2,8 MB (2953048 Byte)
	Action		Purchase in obligation and download of file - 2,8 MB (2953048 Byte)


	Document		Table of contents
	Type		PDF
	Costs		free
	Action		Display of file - 68 kB (69679 Byte)
	Action		Download of file - 68 kB (69679 Byte)

User settings for registered users

You can change your address here or download your paid documents again.

User:	Not logged in.
Actions:	Login / Register Forgotten your password?

Recommendation:

You want to recommend this title?

Review copy:

Here you can order a review copy.

Link:

You want to link this page? Click here.

Export citations:

Text
BibTex
RIS

Abstract:

An abundance of molecules belongs to the class of chiral compounds. They are called enantiomers and share the same physical and chemical properties. Over the course of evolution, nature eventually favored one of two enantiomers of a molecule to build living organisms. As a consequence, every biological entity is capable to distinguish between enantiomers. This can have fatal consequences especially when chiral molecules are used in pharmaceutical drugs. The most prominent example for such a failure was the thalidomide tragedy, which led to the insight that chiral active pharmaceutical ingredients have to be provided as single enantiomers and not as a 50:50 mixture (racemate). Access is, however, complicated by their identity. It is possible to selectively synthesize one enantiomer by chemical means with significant effort. In many cases the final product has to be in the solid state though requiring additional steps such as crystallization or precipitation.
An alternative strategy is the separation of the racemate. Apart from chromatography, which results in a highly pure but very dilute product stream, crystallization is an attractive process combining separation and solid formation in one step. The enantiomers of a certain class of chiral molecules can be separated by so-called preferential crystallization. This technique allows direct crystallization of single enantiomers from a racemic solution. The focus of this work is a systematic experimental and theoretical investigation of preferential crystallization. The aim is to increase robustness and yield as well as the optimization of process conditions, which involves the study of novel operating modes.