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49,80 €ISBN 978-3-8440-5764-5Softcover210 pages41 figures278 g21 x 14,8 cmEnglishThesis
March 2018
Helena Edlund
Pharmacokinetic/pharmacodynamic-guided optimisation of monoclonal antibody therapy in special populations
Monoclonal antibodies constitute a therapeutically and economically important drug class, evident by the growing number on the market and in drug development. Still, sub-optimal use of monoclonal antibodies can result in loss of response or adverse events. In this thesis, pharmacometric modelling and simulation methodologies were applied to contribute to the pharmacokinetic/pharmacodynamic understanding of monoclonal antibodies in two populations, namely children and patients with Crohn's disease.
Keywords: monoclonal antibodies; infliximab; Crohn's disease; clinical pharmacy; mAbs; PK/PD processes of mAbs; anti-drug antibodies
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