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48,80 €ISBN 978-3-8440-8122-0Softcover160 pages45 figures237 g21 x 14,8 cmEnglishThesis
July 2021
Jens Peter Johannsen
Towards Bridging the Gap between Academia and Industrial Application of Enzyme-Based Processes
A Multi-Enzyme Cascade Reaction in a Miniplant Two-Phase System
For the first time, an integrated multi-enzyme cascade reaction in a two-phase system is scaled up to miniplant-scale, mathematically modeled, and optimized through computer-aided process development methods in an effort towards reducing the gap between the academic research in biotechnology and the industrial application of enzyme-based processes identified in a significant number of literature reviews. After characterization in laboratory scale, the reference reaction system is implemented to a miniplant-scale reactor setup and mathematically modeled in Aspen Custom Modeler®. Validated with independent experimental data, the process model is then used for mathematical process optimization.
Keywords: Biotechnology; Process Modeling; Process Simulation; Process Optimization
Berichte aus dem Institut für Prozess- und Anlagentechnik der TU Hamburg
Edited by Prof. Dr.-Ing. Georg Fieg, Hamburg
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