Solvey Maldonado Torres

Force-induced Bone Adaptation:

A Systems Biology Perspective Towards Therapy Design


Front	Back

ISBN:

978-3-8440-0779-4

Series:

Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg
Herausgeber: Otto-von-Guericke Universität Magdeburg and Institut für Automatisierungstechnik
Magdeburg

Volume:

Keywords:

bone remodeling; bone adaptation; mechanical loading; sensitivity analysis; rational/polynomial systems; semidefinite programming; convex relaxations; set-based methods

Type of publication:

Thesis

Language:

English

Pages:

150 pages

Figures:

48 figures

Weight:

221 g

Format:

21 x 14,8 cm

Bindung:

Paperback

Price:

30,80 € / 61,60 SFr

Published:

February 2012

Buy:

Download:

Available PDF-Files for this title:

You need the Adobe Reader, to open the files. Here you get help and information, for the download.

These files are not printable.


	Document		Abstract
	Type		PDF
	Costs		free
	Action		Diplay of file - 125 kB (127634 Byte)
	Action		Download of file - 125 kB (127634 Byte)


	Document		Document
	Type		PDF
	Costs		7,70 EUR
	Action		Purchase in obligation and display of file - 1,2 MB (1305796 Byte)
	Action		Purchase in obligation and download of file - 1,2 MB (1305796 Byte)


	Document		Table of contents
	Type		PDF
	Costs		free
	Action		Diplay of file - 79 kB (80586 Byte)
	Action		Download of file - 79 kB (80586 Byte)

User settings for registered users

You can change your address here or download your paid documents again.

User:	Not logged in.
Actions:	Login / Register Forgotten your password?

Recommendation:

You want to recommend this title?

Review copy

Here you can order a review copy.

Link

You want to link this page? Click here.

Abstract

In this work, the author employs a systems biology approach to get a system-level understanding of the biological mechanisms driving the adaptive response of bone to increased/decreased mechanical loads. To this end, a mathematical model describing the adaptation of bone due to mechanical and chemical stimuli is developed and qualitatively validated. Novel set-based methods are employed to analyze the steady state effects of parameter uncertainty and robustness of the model. Furthermore, these set-based methods are used to explore the design of new treatments combining the beneficial effects of mechanical and non-mechanical agents for specific bone disorder conditions.