Solvey Maldonado Torres

Force-induced Bone Adaptation:

A Systems Biology Perspective Towards Therapy Design


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ISBN:

978-3-8440-0779-4

Series:

Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg
Herausgeber: Otto-von-Guericke Universität Magdeburg and Institut für Automatisierungstechnik
Magdeburg

Volume:

Keywords:

bone remodeling; bone adaptation; mechanical loading; sensitivity analysis; rational/polynomial systems; semidefinite programming; convex relaxations; set-based methods

Type of publication:

Thesis

Language:

English

Pages:

150 pages

Figures:

48 figures

Weight:

221 g

Format:

21 x 14,8 cm

Binding:

Paperback

Price:

30,80 € / 61,60 SFr

Published:

February 2012

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Abstract:

In this work, the author employs a systems biology approach to get a system-level understanding of the biological mechanisms driving the adaptive response of bone to increased/decreased mechanical loads. To this end, a mathematical model describing the adaptation of bone due to mechanical and chemical stimuli is developed and qualitatively validated. Novel set-based methods are employed to analyze the steady state effects of parameter uncertainty and robustness of the model. Furthermore, these set-based methods are used to explore the design of new treatments combining the beneficial effects of mechanical and non-mechanical agents for specific bone disorder conditions.