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30,80 €ISBN 978-3-8440-0779-4Softcover150 pages48 figures221 g21 x 14,8 cmEnglishThesis
February 2012
Solvey Maldonado Torres
Force-induced Bone Adaptation:
A Systems Biology Perspective Towards Therapy Design
In this work, the author employs a systems biology approach to get a system-level understanding of the biological mechanisms driving the adaptive response of bone to increased/decreased mechanical loads. To this end, a mathematical model describing the adaptation of bone due to mechanical and chemical stimuli is developed and qualitatively validated. Novel set-based methods are employed to analyze the steady state effects of parameter uncertainty and robustness of the model. Furthermore, these set-based methods are used to explore the design of new treatments combining the beneficial effects of mechanical and non-mechanical agents for specific bone disorder conditions.
Keywords: bone remodeling; bone adaptation; mechanical loading; sensitivity analysis; rational/polynomial systems; semidefinite programming; convex relaxations; set-based methods
Contributions in Systems Theory and Automatic Control, Otto-von-Guericke-Universität Magdeburg
Edited by Otto-von-Guericke Universität Magdeburg and Institut für Automatisierungstechnik, Magdeburg
Volume 2
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